CYRAMZA® (Ramucirumab)

The FDA on April 24, 2015 approved CYRAMZA® for use in combination with FOLFIRI for the treatment of patients with metastatic ColoRectal Cancer (mCRC), whose disease has progressed on a first line Bevacizumab, Oxaliplatin and Fluoropyrimidine containing regimen. CYRAMZA® is a recombinant human monoclonal IgG1 antibody that binds to the human vascular endothelial growth factor- receptor 2 (VEGF-R2), preventing the interaction of VEGF-R2 to its ligands. CYRAMZA® was approved earlier in 2014 for the treatment of patients with advanced Gastric or GastroEsophageal Junction (GEJ) adenocarcinoma and in December 2014, for use in combination with TAXOTERE® (Docetaxel) for the treatment of patients with metastatic Non Small Cell Lung Cancer (NSCLC). CYRAMZA® injection for intravenous infusion, is a product of Eli Lilly and Company.