⇚ Regimen OPDIVO® and YERVOY® - for Malignant Melanoma Medical Name OPDIVO® (Nivolumab) and YERVOY® (Ipilimumab) - for advanced Malignant Melanoma Cycles Given N/A Delivery Phases 2 Special Instructions In the First Phase, OPDIVO® followed by YERVOY® is administered every 3 weeks for 4 doses. In the Second Phase, OPDIVO® is given as a single agent every 2 weeks until disease progression or unacceptable toxicity. Monitor closely for immune mediated end organ damage such as Pneumonitis, Colitis, Hepatitis, Nephritis and Endocrinopathies. References First Phase Drug Mode Given Standard Dose Days to Be Given Frequency Solution Volume Duration YERVOY® (Ipilimumab) IV 3 mg/kg D1 q21 NSS 250 cc 90 minutes OPDIVO® (Nivolumab) IV 3 mg/kg D1 q21 NSS 250 cc 60 minutes Second Phase Drug Mode Given Standard Dose Days to Be Given Frequency Solution Volume Duration OPDIVO® (Nivolumab) IV 3 mg/kg D1 q14 NSS 250 cc 60 minutes